Code System Concept

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Code System Concept

Code System Concept Code	234451005
Code System Concept Name	Acquired von Willebrand disease (disorder)
Code System Preferred Concept Name	Acquired von Willebrand disease (disorder)
Concept Status	Published
Concept Status Date	09/01/2024
Code System Name	SNOMED-CT

Concept Relationships
Concept Details

Concept Details

Code System Code	PH_SNOMED-CT
Code System OID	2.16.840.1.113883.6.96
HL7 Table 0396 Code	SCT
Superseded By Concept
SDO Concept Status	Active
SDO Concept Status Date	07/31/2018
SDO Date Created	01/31/2002
SDO Date Revised	07/31/2018
Description	Acquired von Willebrand disease (VWD) is a rare bleeding disorder marked by the same biological anomalies as those seen in hereditary von Willebrand disease (VWD) but which occurs in association with another underlying pathology, generally in elderly patients without any personal or family history of bleeding anomalies. There are three principle pathogenic mechanisms described which are firstly the presence of autoantibodies (inhibiting or noninhibiting) that form immune complexes with the von Willebrand factor (VWF) leading to rapid clearance of VWF from the circulation. Secondly, absorption of VWF onto malignant cell clones and thirdly the increased proteolysis of high molecular weight VWF multimers under abnormal blood conditions caused by cardiovascular malformations (such as aortic valve stenosis).
Sequence

Extended Properties

No extended properties.

Concept Alternate Designations

SDO Designation ID	Concept Designation Description	Status	Designation Type	PHIN Preferred Term Flag	Code Flag
1784908015	Acquired von Willebrand syndrome	Active	Synonym	false	false
1784909011	Acquired von Willebrand disease	Active	Synonym	false	false
351278015	Acquired von Willebrand's disease	Active	Synonym	false	false
351279011	vWD - Acquired von Willebrand's disease	Active	Synonym	false	false

Associated Value Sets

Value Set Name	Version(s)
Clinical Finding (NNDSS)	2 , 1
Disease	10 , 9 , 8 , 7 , 6 , 5 , 4 , 3 , 2 , 1
Problem Value Set	3 , 2

Parent Concepts Parent Concepts Parent/Child (Relationship Type) Acquired coagulation disorder (disorder) {234466008 , SNOMED-CT } von Willebrand disorder (disorder) {128105004 , SNOMED-CT }	Other Relationships No other relationships present.
Child Concepts Acquired von Willebrand disease (disorder) {234451005 , SNOMED-CT } Parent/Child (Relationship Type) von Willebrand factor inhibitor disorder (disorder) {41106001 , SNOMED-CT }

Page last reviewed:June 20, 2024
Page last updated:June 20, 2024
Content source:
- Centers for Disease Control and Prevention,